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产品介绍 当前位置:首页 > 产品介绍 > 新陈代谢系列

类型: 新陈代谢系列

名称:新陈代谢笼

MMC100 Metabolic Cage

型号:MMC100

  • 产品介绍
  • 产品特点
  • 产品参数
  • 产品应用
  • 文献参考

MMC100新陈代谢笼用于小鼠的实验,是一个独立的单元,设计用于单个小鼠的长达24小时的实验。该代谢笼具有独特的功能,可以最大程度的减少尿液收集的污染。

 

MMC100新陈代谢笼由不锈钢和丙烯酸制成,有以下的8个组件:
1  顶部圆筒
2  底部圆筒 
3  底板
4  收集漏斗
5  盖子
6  喂食器

 

收集步骤:
新陈代谢笼的高效收集的关键在于收集漏斗。它收集小鼠的尿液小滴,使之慢慢的聚集到中间的球状物上,直到足够多后就会滴落到下面的收集容器中。任何的杂质,即使没有被底板排除在外,也会被漏斗排除在外,使杂质不会进入到收集容器中,得到完整、清洁的样品。

 

肥胖设计:
肥胖的设计和标准的代谢笼有一个区别:在顶部的圆筒上的臂是45?角的,以便于安装超重小鼠的喂食和喂水器。肥胖的设计包括先前提到的标准设计相同的功能。此外,虽然最初是为肥胖小鼠设计的,但是这个笼子也可以适用于标准的小鼠。

 

冷却系统设计:
冷却系统分为两部分,包括绝缘笼基座和连接到冷却系统的基座插头。 这个笼子提供了一个方便的方法去保持整个收集过程中的样品温度在或低于45?F(7?C)。

 

1    易于使用、安装和清洁
2    精确的从粪便中分离尿液
3    很少的组成结构和耗材
4    由坚固耐用的丙烯酸材料制作
5    不锈钢材料的底板和收集漏斗  
6    O形环密封圈用于刚性连接    
7    透明设计,便于观察  
8    提供24小时、2-5ml的收集 
9    尿液收集容器是可移动的
10  符合实验动物使用和护理的要求 
11  可选的肥胖和冷却系统设计

1    易于使用、安装和清洁
2    精确的从粪便中分离尿液
3    很少的组成结构和耗材
4    由坚固耐用的丙烯酸材料制作
5    不锈钢材料的底板和收集漏斗 
6    O形环密封圈用于刚性连接
7    透明设计,便于观察 
8    提供24小时、2-5ml的收集
9    尿液收集容器是可移动的
10  符合实验动物使用和护理的要求
11  可选的肥胖和冷却系统设计

新陈代谢笼可用于多种研究,包括(但不仅仅限于):
1 药物治疗的效果  
2 肾功能的研究
3 尿蛋白排泄
4 每日摄入的食物和水
5 表型
6 评价标准或干预的代谢功能
7 尿排泄量
该代谢笼也可以改良成用于肥胖小鼠,或者/和包含一个绝缘的基座以链接CCS2000冷却系统。

Oral Candidaadministration in a Clostridium difficile mouse model worsens disease severitybut is attenuated by Bifidobacterium Wimonrat Panpetch, Naraporn Somboonna, +4 authors Asada Leelahavanichkul  PloS one2019

Gut fungi may influence the course of Clostridiumdifficile infection either positively or negatively for the host. Fungi are notprominent in the mouse gut, and C. albicans, the major human… (More)

 

The Role ofAngiotensin II in Experimental Acute Kidney Injury and Cardiorenal Failure  Sofia J?nsson 2019

J?nsson, S. 2019. The Role of Angiotensin II inExperimental Acute Kidney Injury and Cardiorenal Failure. Digital ComprehensiveSummaries of Uppsala Dissertations from the Faculty of Medicine 1554.… (More)

 

The HormoneFGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol.  Parkyong Song, Christoph Zechner, +11 authors Steven Anthony Kliewer  Cell metabolism  2018

Alcohol and ketogenic diets increase waterconsumption. Here, we show that the hormone FGF21 is required for this drinkingresponse in mice. Circulating levels of FGF21 are increased by alcohol… (More)

 

The Synergy ofEndotoxin and (1→3)-β-D-Glucan, from Gut Translocation, Worsens Sepsis Severityin a Lupus Model of Fc Gamma Receptor IIb-Deficient Mice. Jiraphorn Issara-Amphorn, Saowapha Surawut, +7 authors Asada Leelahavanichkul  Journal ofinnate immunity  2018

We investigated the influence of spontaneous gutleakage upon polymicrobial sepsis in a lupus model with Fc gamma receptorIIb-deficient (FcGRIIb-/-) mice aged 8 and 40 weeks, as representing… (More)

 

A companion tothe preclinical common data elements for physiologic data in rodent epilepsymodels. A report of the TASK3 Physiology Working Group of the ILAE/AES JointTranslational Task Force  Jan A. Gorter, Erwin A. van Vliet, +7 authors Astrid Nehlig Epilepsia open  2018

The International League Against Epilepsy/AmericanEpilepsy Society (ILAE/AES) Joint Translational Task Force created the TASK3working groups to create common data elements (CDEs) for various… (More)

 

Remote ischemicpost-conditioning promotes hematoma resolution via AMPK-dependent immuneregulation  Kumar Vaibhav, Molly Braun, +15 authors Krishnan M Dhandapani  TheJournal of experimental medicine  2018

Spontaneous intracerebral hemorrhage (ICH) producesthe highest acute mortality and worst outcomes of all stroke subtypes. Hematomavolume is an independent determinant of ICH patient outcomes,… (More)

 

Increasedsusceptibility against Cryptococcus neoformans of lupus mouse models(pristane-induction and FcGRIIb deficiency) is associated with activatedmacrophage, regardless of genetic background  Saowapha Surawut, Jiradej Makjaroen, +5 authors Asada Leelahavanichkul  Journal ofMicrobiology  2018

The severity of cryptococcosis in lupus from varyinggenetic-backgrounds might be different due to the heterogeneity oflupus-pathogenesis. This study explored cryptococcosis in lupus mouse modelsof… (More)

 

Mitochondrialuncoupling has no effect on microvascular complications in type 2 diabetes  Lucy M Hinder, Kelli M Sas, +11 authors Eva L. Feldman Scientific Reports   2018

Diabetic peripheral neuropathy (DPN), diabetic kidneydisease (DKD), and diabetic retinopathy (DR) contribute to significantmorbidity and mortality in diabetes patients. The incidence of these… (More)

 

BrainPhospholipid Precursors Administered Post-Injury Reduce Tissue Damage andImprove Neurological Outcome in Experimental Traumatic Brain Injury  Orli Thau-Zuchman, Rita N. Gomes, +6 authors Adina Teodora Michael-Titus  Journal ofneurotrauma  2018

Traumatic brain injury (TBI) leads to cellular loss,destabilization of membranes, disruption of synapses and altered brainconnectivity, and increased risk of neurodegenerative disease. A… (More)

 

Chronic InsulinInfusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) LevelsDespite Molecular Changes in the Kidney Predicting Greater Endothelial NOSynthase Activity in Mice  Maurice Bruce Fluitt, Sophia Rizvi, +4 authors Carolyn M A Ecelbarger  Internationaljournal of molecular sciences  2018

Insulin therapy is often needed to overcome insulinreceptor resistance in type 2 diabetes; however, the impact of providingadditional insulin to already hyperinsulinemic subjects is not clear. We… (More)

 

Telmisartan prevents diet-induced obesity and preservesleptin transport across the blood-brain barrier in high-fat diet-fed mice  Franziska Schuster, Gianna Huber, +5 authors Walter Raasch Pflügers Archiv - European Journal ofPhysiology  2018

Obesity is a global health problem and treatmentoptions are still insufficient. When chronically treated with the angiotensinII receptor blocker telmisartan (TEL), rodents do not develop… (More)

 

Thymosin β4Deficiency Exacerbates Renal and Cardiac Injury in Angiotensin-II-InducedHypertension.  Naveen P. G. Kumar, Tang-dong Liao, Cesar A Romero, Mani Maheshwari, Edward L. Peterson, Oscar A. Carretero  Hypertension  2018

Thymosin β4 (Tβ4), a ubiquitous peptide, regulatesseveral cellular processes that include cell morphology, wound healing, andinflammatory response. Administration of exogenous Tβ4 is protective in… (More)

 

Experimentalautoimmune encephalomyelitis (EAE) up-regulates the mitochondrial activity andmanganese superoxide dismutase (MnSOD) in the mouse renal cortex  Balamurugan Packialakshmi, Xiaoming Zhou PloS one  2018

Increases of the activity of mitochondrial electrontransport chain generally lead to increases of production of ATP and reactiveoxygen species (ROS) as by-products. MnSOD is the first line of… (More)

 

In VivoAnticancer Activity of a Nontoxic Inert Phenolato Titanium Complex: HighEfficacy on Solid Tumors Alone and Combined with Platinum Drugs  Nitzan Ganot, Ori Briaitbard, Asaad Gammal, Joseph Tam, Jacob Hochman, Edit Y Tshuva ChemMedChem  2018

Due to the toxicity of platinum compounds used in theclinic as anticancer chemotherapies, titanium serves as a safe and attractivealternative. Lately, we introduced a new family of Ti complexes… (More)

 

RSK2 contributesto myogenic vasoconstriction of resistance arteries by activating smooth musclemyosin and the Na+/H+ exchanger Mykhaylo V Artamonov, Swapnil K. Sonkusare, +8 authors Avril V Somlyo  Science Signaling  2018

Smooth muscle contraction is triggered whenCa2+/calmodulin-dependent myosin light chain kinase (MLCK) phosphorylates theregulatory light chain of myosin (RLC20). However, blood vessels from… (More)

 

Proreninindependently causes hypertension and renal and cardiac fibrosis incyp1a1-prorenin transgenic rats Guangyu Zhou, Jie Wu, +4 authors Yufeng Huang  Clinical science  2018

Plasma prorenin is commonly elevated in diabeticpatients and appears to predict the development of diabetic nephropathy.However, the pathological role of prorenin is unclear. In the presentstudy,… (More)

 

Enhanced RenalIschemia-Reperfusion Injury in Aging and Diabetes.  Yoshikazu Muroya, Xiaochen He, +4 authors Richard Joseph Roman  American journalof physiology. Renal physiology  2018

The incidence and severity of acute kidney injury isincreased in diabetic patients and with aging. However, the mechanisms involvedhave not been clearly established. The present study examined the… (More)

 

SweetTasteReceptors Mediated ROS-NLRP3 Inflammasome Signaling Activation:Implications forDiabetic Nephropathy

Luping ZhouWei Huang, +9 authors Yong Xu  Journal of diabetes research  2018

Previous studiesdemonstratedthat ROS-NLRP3 inflammasome signaling activation was involved inthepathogenesis of diabetic nephropathy (DN). Recent research has shown thatsweettaste receptors… (More)

 

Sesamin alleviates blood-brain barrierdisruption inmice with experimental traumatic brain injury

Ying-liang LiuZhi-ming Xu, +5 authors Heng-Li Tian Acta Pharmacologica Sinica  2017

Sesamin, a majorlignan of sesameoil, was reported to have neuroprotective effects in severalbrain injurymodels. However, its protective action in maintaining blood-brainbarrier (BBB)integrity… (More)

 

Generation and phenotypic analysis ofmice lacking allurea transporters.

Tao JiangYingjie Li, +5 authors Baoxue Yang  Kidney international  2017

Ureatransporters (UT) are afamily of transmembrane urea-selective channel proteinsexpressed in multipletissues and play an important role in the urineconcentrating mechanism of themammalian… (More)

 

miR-155 Deficiency AmelioratesAutoimmune Inflammationof Systemic Lupus Erythematosus by Targeting S1pr1 inFaslpr/lpr Mice.  

Qian XinJiangxia Li, +12 authors Qi-ji Liu  Journal of immunology  2015

MicroRNA-155(miR-155) waspreviously found involved in the development of systemic lupuserythematosus(SLE) and other autoimmune diseases and the inflammatoryresponse; however, thedetailed… (More)

 

MYH9 E1841K Mutation AugmentsProteinuria and PodocyteInjury and Migration.  Sylvia CechovaFan DongFang Cheng ChanMichael J. KelleyP. RuizThu H Le  Journal of the American Society ofNephrology…  2018

Intronicvariants of the MYH9gene that encodes the nonmuscle myosin heavy chain IIA areassociated withdiabetic nephropathy in European Americans and with sicklecelldisease-associated… (More)

 

High salt intake reprioritizes osmolyteand energymetabolism for body fluid conservation.

Kento KitadaSteffen Daub, +21 authors Jens M. Titze  The Journal of clinical investigation  2017

Natriureticregulation ofextracellular fluid volume homeostasis includes suppression ofthe renin-angiotensin-aldosteronesystem, pressure natriuresis, and reducedrenal nerve activity, actionsthat… (More)

 

Podocyte-specific knockout ofcyclooxygenase 2exacerbates diabetic kidney disease.

Liming WangYonggang Sha, +4 authors Robert F Spurney  American journal of physiology. Renalphysiology  2017

Enhancedexpression ofcyclooxygenase 2 (COX2) in podocytes contributes to glomerularinjury indiabetic kidney disease, but some basal level of podocyte COX2expression mightbe required to promote… (More)

 

From Newborn to SenescenceMorphological andFunctional Remodeling Leads to Increased Contractile Capacityof Arteries.

Ivan Ivi?Zoltán VámosPeter Cseploákos Koller  The journals of gerontology. Series A,Biological…  2017

Aging inducessubstantialmorphological and functional changes in vessels. We hypothesizedthat due tomorphological remodeling the total contractile forces of arteriesincrease,especially in older… (More)

 

Acute genetic ablation of pendrinlowers bloodpressure in mice.  Francesco TrepiccioneChristelle Soukaseum, +10 authors Dominique Eladari  Nephrology, dialysis, transplantation :official…  2017

BackgroundPendrin, thechloride/bicarbonate exchanger of β-intercalated cells of therenal connecting tubuleand the collecting duct, plays a key role in NaClreabsorption by the distalnephron.… (More)

 

Simultaneous detection of thetetrachloroethylenemetabolites S-(1,2,2-trichlorovinyl)glutathione,S-(1,2,2-trichlorovinyl)-L-cysteine,andN-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine in multiple…

Yu-Syuan LuoJoseph A. CichockiT. J. McDonaldIvan Rusyn Journal of toxicology andenvironmentalhealth…  2017

Tetrachloroethylene(perchloroethylene;PERC) is a high-production volume chemical and ubiquitousenvironmental contaminantthat is hazardous to human health. Toxicityattributed to PERC ismediated… (More)

 

Marine Animal Forests

Sabrina H RossiLorenzo BramantiAndrea GoriCovadonga Orejas  Springer International Publishing  2017

In the marinebenthos,megabenthic communities dominated by sessile sus-pensionfeeders (such assponges, corals, and bivalves) formthree-dimensionalstructures which providearchitectural… (More)

 

Effects ofN‐acetyl‐seryl‐asparyl‐lysyl‐proline onblood pressure, renal damage, andmortality in systemic lupus erythematosus

Pablo NakagawaJuan X. Masjoan‐Juncos, +6 authors Oscar A. Carretero  Physiological reports  2017

Systemic lupuserythematosus(SLE) is an autoimmune disease with a high prevalence ofhypertension. NZBWF1(SLE-Hyp) mice develop hypertension that can be preventedby modulating T cells.The peptide… (More)

 

Chronic PARP-1 inhibition reducescarotid vesselremodeling and oxidative damage of the dorsal hippocampus inspontaneouslyhypertensive rats

Krisztián Er?sKlara Magyar, +8 authors Robert Halmosi PloS one 2017

Vascularremodeling duringchronic hypertension may impair the supply of tissues withoxygen, glucose andother compounds, potentially unleashing deleteriouseffects. In this study, weused… (More)

 

, David Webb , Yuri Kotelevtsev andretention and Breceptors causes hypertension and sodium Combined knockout ofcollecting ductendothelin A

Donald E KohanYuqiang Ge, +18 authors Brian D. Cain  2017

 

Radiobiology and Radiation Hormesis

Dr. Charles L. Sanders  Springer International Publishing  2017

 

 

Human umbilical cord Wharton jellycells promoteextra-pancreatic insulin formation and repair of renal damage inSTZ-induceddiabetic mice  Martin MaldonadoTian-hua HuangLujun YangLan XuLian Ma  Cell Communication and Signaling  2017

We evaluated thetherapeuticeffect and fate of high doses of human umbilical cord Wharton jellycells(hUCWJCs) after IP administration to streptozotocin (STZ)-induceddiabetic mice.Type 1 diabetes… (More)

 

Direct and IndirectMineralocorticoidEffects Determine Distal Salt Transport.

AndrewScott TerkerBethzaidaYarbrough+7 authorsDavidH. Ellison  Journal of theAmerican Society ofNephrology…  2016

Excess aldosterone isanimportant contributor to hypertension and cardiovascular disease.Conversely,low circulating aldosterone causes salt wasting and hypotension.Aldosteroneactivates… (More)

 

A time-courseanalysis of changes incerebral metal levels following a controlled corticalimpact.

StuartD. PortburyDominicJ. HareCharlotteJ SgambelloniDavidI FinkelsteinPaulA. Adlard  Metallomics :integrated biometal science 2016

Traumatic brain injury (TBI)iscomplicated by a sudden and dramatic change in brain metal levels,includingiron (Fe), copper (Cu) and zinc (Zn). Specific 'metallo-pathological'featuresof TBI… (More)

 

MARINE PLASTIC DEBRISAND MICROPLASTICSGlobal lessons and research to inspire action and guidepolicy change Advancecopy  FláviaPereiraHaoChen+5 authorsDeniseHardesty  2016

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Impact ofAngiotensin Type 1A Receptorsin Principal Cells of the Collecting Duct onBlood Pressure and Hypertension. 

DaianChenJohannesStegbauer

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